71 Effects of Periparturient Vaginal Betadine Lavages on Dam and Neonatal Immune Responses

Abstract The vaginal microbiota (VM) is one of the initial contacts neonate with microorganisms and can attribute to neonatal health outcomes. impacts an altered VM on post-partum dam immune responses has not been evaluated. Betadine lavages (BL) have used mitigate bacterial infections within reproductive tract by ablating VM. Thus, this study aimed determine if passive transfer in dams & calves. Commercial beef cows (n = 22) were randomly assigned either control group (CON) or BL treatment (BTL) two weeks before calving. Treatment bags infused into anterior vagina received 1 3 treatments depending calving date. Blood samples gathered from calf at 0, 5, 30 60 days post-partum. Processed blood serum colostrum stored -80°C. Calf (0 d) analyzed for immunoglobulin (IgG) concentration via a commercial ELISA. A D2Dx testing kit was status both calves 1,5, 30, using gold nanoparticles as pathogen substitute identify system factors samples. test produces numerical score that be correlated response strength. All IgG data R software. repeated measures ANOVA (SAS software version 9.4). There no difference between CON BTL calves, represented significant differences (P 0.62) 0.32) concentrations IgG. In dams, there main effect day decreasing postpartum compared 0d < 0.001),5d 0.001), 30d 0.001). where increased on5d 0.046) but decreased d 5 0.005). Moreover, 0 0.001) 60. tendency 0.08) CON. Interestingly, fluctuated While full elucidation causes behind these fluctuations limited, more research evaluating their implications warranted.